Gene Research Tool Helps Pinpoint Type 2 Diabetes Gene Variations

The field of genetic research is exploding, as more genes and gene variations are discovered and studied. Many genes have already been identified with some major diseases and conditions, such as cancers, heart disease and diabetes.

Gene variations that signal disease sequences are of special interest to scientists. These variations are called SNPs (single nucleotide polymorphisms).

With over 500,000 genes in the human genome, it's been slow going for scientists as they try to weed through them to find out which SNPs are responsible for chronic diseases that affect us.

Until now, the process of finding the genes and gene clusters responsible for diabetes has been a little like trying to find needles in a haystack.

A new software tool, developed at Michigan Technological University, may make finding genes and gene clusters that have a marked effect on complicated diseases easier. Using the tool has enabled scientists to pinpoint 11 gene variations, or SNPs, that are associated with type 2 diabetes.

The software enables scientists to focus on a more specific array of genes. It is able to narrow the selection from the thousands of genes that make up the human genome down to a more manageable group of the genes and gene variations most likely to be linked to disease. The test goes further by using statistical methods to detect which variations act individually and which ones act in combination.

Qiuying Sha, an assistant professor of mathematical sciences at Michigan Technological University, says, "With chronic, complex diseases like Parkinson's, diabetes and ALS [Lou Gehrig's disease], multiple genes are involved. You need a powerful test."

Tools that help make identifying gene variations easier may help scientists find the cause, and ultimately the cure, for type 2 diabetes.

More on gene research in type 2 diabetes:

• Racial and Genetic Risk Factors for Diabetes
• Do You Have the Diabetes Gene?
• Diabetes Research

Michigan Technological University Press Release

_Sources:

(2008, March 26). The Science Behind the Human Genome Project. Retrieved March 29, 2008, from Human Genome Project Information Web site: http://www.ornl.gov/sci/techresources/Human_Genome/project/info.shtml

Goodrich, M. Researchers Link 11 Genetic Variations to Type 2 Diabetes. Retrieved March 29, 2008, from Michigan Tech News/Media Web site: http://www.admin.mtu.edu/urel/news/media_relations/673