What Is American Ginseng?

American ginseng (Panax quinquefolius) is a medicinal herb with antioxidant benefits that protect against cell damage and inflammation. Supplements containing American ginseng may improve fatigue, boost memory, and reduce the duration of colds and flu, but more research is needed to confirm its benefits.

American ginseng is considered an adaptogen, which some believe can help the body overcome physical, emotional, and environmental stress. It also contains chemicals called ginsenosides, which may help to lower blood sugar.

Types of American Ginseng

American ginseng is a distinctive type of ginseng used in traditional Chinese medicine. American ginseng and Asian ginseng (Panax ginseng) are both considered true ginseng in that they contain an organic chemical called ginsenoside.

Even so, American ginseng has a different chemical makeup and "cooler" yin qualities than Asian ginseng. It is also less stimulating. Because of this, American ginseng is widely exported to Asia where it is highly valued for its cooling and sedative effects.

Siberian ginseng (Eleutherococcus senticosus) is not a true ginseng, It is a small, woody shrub with blackberry-like fruit found in northeastern Asia. While it is also used in traditional Chinese medicine, neither the berries, leaves, stalks, nor roots contain ginsenoside.

Uses of American Ginseng

The evidence supporting the health benefits of American ginseng is limited, most of which comes from lab and animal studies. Human trials are lacking.

With that said, a growing body of research suggests that American ginseng may be beneficial in the treatment of fatigue, poor memory, diabetes, and viral respiratory infections like colds and flu.

Fatigue

A 2018 review of four studies suggests that American ginseng may help relieve fatigue caused by chronic illnesses ranging from chronic fatigue syndrome (CFS) to cancer. The most significant benefit was seen in people who took 2,000 milligrams (mg) daily for eight weeks.

Similar results were seen in a 2019 review examing the effects of American ginseng on people with cancer-related fatigue. In this study, the benefit was greatest in people undergoing active treatment, like chemotherapy or radiation.

As an added bonus, American ginseng does not interact with commonly prescribed chemotherapy drugs like tamoxifen, doxorubicin, methotrexate, or fluorouracil.

Memory

Limited evidence suggests that American ginseng may improve cognitive function in some people. This includes the ability to learn, think, reason, and remember.

A 2015 study reported that healthy adults who received a single 200 mg dose of an American ginseng extract (called Cereboost) had increased working memory, peaking within three hours of the dose. The findings were limited by the small size of the study (52 adults) and the lack of a control group (meaning a group given a sham placebo).

A 2022 study involving 61 adults showed longer-lasting improvements in working memory after taking 200 mg of Cereboost daily for two weeks. For this study, a control group was included, but the findings were limited by the fact that the research was funded by the manufacturer, Naturex SA.

An unrelated study published in 2012 reported that an American ginseng extract taken twice daily for four weeks improved the working memory of 32 people with schizophrenia compared to a matched set of adults given a placebo.

Diabetes

A 2014 review of 16 ginseng trials concluded that the fasting blood sugar was modestly lowered by taking ginseng. Three of the 16 studies looked at American ginseng specifically.

A 2019 study involving 24 adults with well-controlled type 2 diabetes showed that a 3,000 mg dose of American ginseng taken daily helped control blood sugar. At the end of the eight-week study, the people given American ginseng had lower hemoglobin A1C levels, fasting blood sugar, and systolic blood pressure than those given a placebo.

The findings were limited by the fact that the participants' blood sugar was already controlled by medications. At present, there is no evidence that ginseng is able to manage diabetes on its own.

Cold and Flu

According to a 2017 review of studies in the Journal of Complementary and Alternative Medicine, American ginseng may offer protection against common viral respiratory infections like colds and flu. This supported earlier research in which American ginseng appeared to reduce the risk and duration of colds and flu in older adults with weakened immune systems.

A 2020 analysis published in Complementary Therapy and Medicine suggested that American ginseng may help prevent or treat seasonal respiratory infections in some people, but that the evidence wasn't strong enough to offer a clear conclusion.

Additional Uses

Preliminary studies have investigated American ginseng for the following conditions:

• Alzheimer's disease
• Ischemic stroke
• Heart failure
• Having obesity
• Cancer

What Are the Side Effects of American Ginseng?

American ginseng is generally regarded as safe. In clinical trials, doses of 2,000 mg daily were well-tolerated and had the same rate of side effects as a placebo.

Possible side effects include:

• Nausea
• Insomnia
• Headache
• Rash
• Flu-like symptoms
• Low blood sugar
• Diarrhea
• Vaginal bleeding
• Breast pain

The long-term side effects of ginseng use aren't known.

Precautions

Some groups of people should take special precautions when using American ginseng and may need to avoid it altogether. These include conditions like:

• Pregnancy and breastfeeding: American ginseng contains ginsenoside, a chemical linked to birth defects in animals. It is unknown if taking American ginseng while nursing is safe.
• Estrogen-sensitive conditions: Conditions like breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids may be worsened because ginsenoside has estrogen-like activity.
• Insomnia: High doses of American ginseng may cause difficulty sleeping.
• Schizophrenia: High doses of American ginseng can increase agitation in people with schizophrenia.
• Surgery: American ginseng should be stopped two weeks before surgery due to its impact on blood sugar.

Dosage: How Much American Ginseng Should I Take?

There is no recommended dosage of American ginseng in any form. Never exceed the recommended dosage on the product label, or ask your healthcare provider for advice.

American ginseng has been studied at the following dosages:

• Adults: 200 to 400 mg by mouth twice daily for three to six months
• Children age 3 to 12: 4.5 to 26 milligrams per kilogram (mg/kg) by mouth daily for three days

At these doses, American ginseng is unlikely to cause toxicity. At higher doses—typically 15 grams (1,500 mg) or more per day—some people develop "ginseng abuse syndrome" characterized by diarrhea, dizziness, skin rash, heart palpitations, and depression.

Drug Interactions

American ginseng may interact with prescription and over-the-counter medications and supplements. These include:

• Warfarin: American ginseng may reduce the blood thinner's effectiveness and increase the risk of blood clotting.
• Monoamine oxidase inhibitors (MAOIs): Combining American ginseng with MAOI antidepressants like Zelapar (selegiline) and Parnate (tranylcypromine) can cause anxiety, restlessness, manic episodes, or trouble sleeping.
• Diabetes medications: American ginseng can cause blood sugar to drop excessively when taken with insulin or other diabetes drugs, leading to hypoglycemia (low blood sugar).
• Progestins: The side effects of the synthetic form of progesterone can be increased if taken with American ginseng.
• Herbal supplements: Some herbal remedies can also lower blood sugar when combined with American ginseng, including aloe, cinnamon, chromium, vitamin D, and magnesium.
  

To avoid interactions, tell your healthcare provider if you intend to use any supplement.

Sources of American Ginseng

American ginseng is an ingredient found in many commercial food products in the United States. It can also be purchased online or in stores in supplement form.

American ginseng is used as an additive in some energy drinks and ginger candies. There are also American ginseng teas sold in grocery stores, supplements stores, and health food shops. Whole dried root and granulated ginseng root can also be used to make teas and tonics.

As a supplement, American ginseng is available as a tablet, capsule, powder, extract, or tincture. Tablets and capsules may be better options than whole root ginseng as you can control the dose.

Store ginseng tea, supplements, and dried root in airtight containers in a cool, dry place. Keep away from children and pets. Discard after one year or by the expiration date on the product label.

Similar Supplements

Some other supplements that may improve cognitive function and decrease stress are:

• Bacopa (Bacopa monnieri)
• Ginkgo (Ginkgo biloba)
• Holy basil (Ocimum tenuiflorum)
• Gotu kola (Centella asiatica)
• Lemon balm (Melissa officinalis)
• Sage (Salvia officinalis)
• Spearmint (Mentha spicata)

Supplements that have been studied for the treatment or prevention of respiratory viruses like the cold or flu include:

• Elderberry
• Maoto
• Licorice root
• Antiwei
• Echinacea
• Carnosic acid
• Pomegranate
• Guava tea
• Bai Shao
• Zinc
• Vitamin D
• Honey
• Nigella

Summary

Limited evidence suggests that American ginseng may help improve fatigue, mental function, diabetes, and respiratory infections like the cold and flu. Side effects and drug interactions are possible, and American ginseng can be dangerous if taken during pregnancy, breastfeeding, or in people with schizophrenia or certain cancers.

In some cases, integrative medicine shouldn't be a substitute for standard medical care. Use first-line treatments, and discuss with your healthcare provider about adding alternatives like American ginseng and other herbal remedies.