A comparison of the only two drugs in the class of thiazolidinediones, seems to project that pioglitazone (Actos) and rosiglitazone (Avandia) carry many of the same general precautions including a warning of "Cardiac Failure and Other Cardiac Effects". The difference seems to be that Avandia showed other cardiovascular adverse events such as cardiac arrest in addition to heart failure in studies, while Actos, appears to show no other cardiovascular adverse events other than increased incidence of heart failure.
Actos should still be prescribed cautiously and people who take Actos should be alert to signs and symptoms of congestive heart failure.
Signs and Symptoms of Congestive Heart Failure - The American Heart Association
- Shortness of breath
- Persistent cough or wheeze
- Swelling in the feet, ankles, legs, or abdomen
- Weight gain
- Fatigue
- Loss of appetite
- Confusion
- Increased heart rate
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Rosiglitazone , have even in Indian populatin a few go in for cardiac failure. Weight gain is another problem. The drug do not show any excessive promising good response, as well many OHD are available without any side effects. It is the right time FDA should withdraw their approval for rosiglitazone